Segmental Resection and Replantation Have a Role for Selected Advanced Sarcomas in the Upper Limb

• DOI: 10.1007/s11999-009-0872-0
• Publication Date: 2009-07-29T17:12:40Z
• Authors: Soo Bong Hahn; Yun Rak Choi; Ho Jung Kang; Kyoo Ho Shin
• Keywords: Adult; Male; Time Factors; Osteosarcoma/pathology; Adolescent; Reconstructive Surgical Procedures/methods; 0206 medical engineering; 610; Bone Neoplasms; 02 engineering and technology; Replantation/methods*; Risk Assessment; Sampling Studies; Osteosarcoma/surgery*; Upper Extremity; Young Adult; Wound Healing/physiology; 617; Neoplasm Invasiveness/pathology*; Humans; Neoplasm Invasiveness; Retrospective Studies; Osteosarcoma; Limb Salvage/methods*; Local/epidemiology; Patient Selection; Recovery of Function; Plastic Surgery Procedures; Limb Salvage; Combined Modality Therapy; Neoplasm Recurrence; Treatment Outcome; Replantation; Female; Neoplasm Recurrence, Local; Bone Neoplasms/pathology; Bone Neoplasms/surgery*; Local/pathology; Follow-Up Studies

Although limb salvage surgery for primary sarcoma of the upper limb is a standard procedure, it often is technically challenging. We asked whether segmental resection and replantation would provide (1) local control and long-term survival and (2) useful limb function in patients who had advanced primary malignant and aggressive tumors of the upper limbs. We retrospectively reviewed six patients treated with this procedure when a wide resection around the tumor could not be achieved with other limb-salvage procedures. Diagnoses included osteosarcoma (two), Ewing's sarcoma (one), leiomyosarcoma (one), and giant cell tumor (two). Four patients had displaced pathologic fractures. Minimum followup was 40 months (mean, 164 months; range, 40-214 months). All but one patient remained disease-free; the patient with Ewing's sarcoma died from the disease 40 months after surgery. The average functional score at last followup was 20 points. The mean grasping and pinching power of the operative hand were 66% and 72% of the contralateral side, respectively. Two patients had complications: one had wound dehiscence that subsequently healed and one had radial nerve palsy that recovered spontaneously by 3 months. Segmental resection and replantation may have a role in selected cases for treatment of advanced primary sarcoma or aggressive giant cell tumor of the upper limb as partial limb salvage.Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.