Trace Element Concentrations in Human Tissues of Death Cases Associated With Secondary Infection and MOF After Severe Trauma

• DOI: 10.1007/s12011-015-0378-4
• Publication Date: 2015-06-04T13:10:46Z
• Authors: Guangtao Xu; Ruibing Su; Bo Li; Junyao Lv; Weiqi Sun; Bo Hu; Xianxian Li; Jiang Gu; Xiaojun Yu
• Keywords: Adult; Male; 0301 basic medicine; 0303 health sciences; Coinfection; Iron; Multiple Organ Failure; Myocardium; Spectrophotometry, Atomic; Brain; Middle Aged; Kidney; 7. Clean energy; Trace Elements; 3. Good health; Hospitalization; Selenium; 03 medical and health sciences; Liver; Humans; Wounds and Injuries; Female; Tissue Distribution; Autopsy; Copper

Proper trace element level is crucial for the organs in maintaining normal physiological functions. Multiple organ failure (MOF) might be added to critically ill patients due to a lack of trace elements. Alterations of trace element levels in brain, heart, liver, and kidney after severe trauma, however, have been little studied so far. In this study, tissue samples of the frontal cortex of the brain, interventricular septum of the heart, right lobe of the liver, and upper pole of the kidney were obtained from forensic autopsies, of which 120 cases died during the 5th to 15th day of hospitalization, whereas the trauma death group and 43 cases immediately died due to severe craniocerebral trauma as the control group. Copper (Cu), iron (Fe), zinc (Zn), and selenium (Se) were quantified by inductively coupled plasma atomic emission spectrophotometry (ICP-AES). Cu, Fe, Zn, and Se concentrations in the brain, heart, liver, and kidney in the trauma group decreased dramatically (p<0.05) compared to the control group. The incidence of secondary infection and multiple organ failure (MOF) in the trauma death group were 78.33 and 29.17%, respectively. The concentrations of all elements exhibited a significant correlation with secondary infection and MOF (p<0.01). Our data suggest that low concentrations of Cu, Fe, Zn, and Se in pivotal organs may contribute to the incidence of secondary infection and MOF after severe trauma, which to some extent results in death.