The Toxicological Risk Assessment of Lead and Cadmium in Valeriana officinalis L., radix (Valerian root) as Herbal Medicinal Product for the Relief of Mild Nervous Tension and Sleep Disorders Available in Polish Pharmacies

• DOI: 10.1007/s12011-021-02691-5
• Publication Date: 2021-04-01T08:03:30Z
• Authors: Kamil Jurowski; Maria Fołta; Barbara Tatar; Mehmet Berkoz; Mirosław Krośniak
• Keywords: Valerian; Radix (gastropod); Phytotherapy

Studies related to the toxicological risk assessment (TRA) of heavy metal impurities (HMIs) in pharmaceuticals are an important issue but there is a lack refereed literature around safety Valeriana officinalis L., radix (Valerian root) as herbal medicinal product (HMP) for relief mild nervous tension and sleep disorders according lead cadmium impurities. The aim study was estimate TRA HMP (n = 5) available Polish pharmacies. In case pharmaceuticals, it particularly control level HMIs accumulated during plant's growth. Perhaps, exposure single dose not relevant; however, justification our studies fact that therapies usually long term. Therefore, even small HMI doses present particular plant may accumulate patient body over period time. Levels were measured by electrothermal atomization atomic absorption spectrometry. levels (independently producer declared composition) quite similar. Our results satisfactory, confirming pharmacies ICH guideline Q3D. To best knowledge, this paper first about content containing root).