The role of sex, adiposity, and gonadectomy in the regulation of irisin secretion

• DOI: 10.1007/s12020-016-0913-x
• Publication Date: 2016-04-07T15:55:33Z
• Authors: M. Zügel; S. Qiu; R. Laszlo; E. Bosnyák; C. Weigt; D. Müller; P. Diel; J. M. Steinacker; U. Schumann
• Keywords: FNDC5; Myokine; Sexual dimorphism; Aerobic Exercise

A sexual dimorphism has been reported for the adipo-myokine irisin at rest and in response to exercise. The effects of male female sex, adiposity, gonadectomy on secretion have not investigated before. objective this study was elucidate regulation as well PGC-1α/FNDC5 mRNA protein expression. We hypothesized that a lack sex hormones by ovariectomy reduces levels inhibits skeletal muscle expression PGC-1α FNDC5. Circulating measured vivo serum samples healthy obese men women acute irisin, FNDC5 mRNA, were ovariectomized (OVX) orchiectomized (ORX) Wistar rats. Serum significantly different between (lean or obese). However, aerobic exercise, increased more lean versus (p ≤ 0.05). In individuals, resting concentrations higher compared subjects 0.001) exercise blunted. Only gonadal OVX but ORX rats 0.01) resulted body weight 0.01), adipose tissue content 0.05), without altering Testosterone treatment leads reduced affecting FDNC5 levels. show exists normal-weight subjects. OVX, which is associated with adiposity insulin insensitivity, increases basal This may be an early sign metabolic disturbances menopause, such developing resistance attempt organism improve glucose metabolism.