Serum osteoglycin is stable during various glycemic challenges in healthy men

• DOI: 10.1007/s12020-024-03789-1
• Publication Date: 2024-03-28T17:01:50Z
• Authors: Jakob Starup-Linde; Sidse Westberg-Ra...; Rikke Viggers; Zheer Kejlberg Al...; Aase Handberg; Peter Vestergaard; Søren Gregersen
• Keywords: Adult; Male; Blood Glucose; 0301 basic medicine; Cross-Over Studies; Osteoglycin; Research; Oral glucose tolerance test; Fasting; Glucose Tolerance Test; Young Adult; 03 medical and health sciences; Glucose; Isoglycemic intravenous glucose infusion; Hyperglycemia; Humans; Insulin

Abstract Purpose Osteoglycin is hypothesized to be metabolically active and may enhance insulin action. We hypothesized that osteoglycin levels increase during hyperglycemia as a physiological response to enhance the effects of insulin.

Methods Eight healthy males were included in a cross-over study consisting of three study days following an 8 h fast. First, we performed an oral glucose tolerance test (OGTT); second, an isoglycemic intravenous glucose infusion (IIGI); and third, a control period consisting of a three hour fast. We analyzed blood samples for circulating osteoglycin levels during the study days. Repeated measures ANOVA was performed to compare levels of s-osteoglycin between OGTT, IIGI, and the fasting control.

Results There were no differences in baseline osteoglycin levels among study days (p > 0.05). We observed no significant changes neither in absolute s-osteoglycin levels by time (p = 0.14) nor over time by study day (p = 0.99). Likewise, we observed no significant changes in percentage s-osteoglycin levels neither by time (p = 0.11) nor over time by study day (p = 0.89).

Conclusion We found that s-osteoglycin levels were stable for three hours during OGTT, IIGI, and fasting in healthy males. Based on the present study, circulating s-osteoglycin levels may be measured independently of fasting or non-fasting conditions. Furthermore, circulating physiological levels of glucose and insulin did not affect s-osteoglycin levels.