FocusDET, A New Toolbox for SISCOM Analysis. Evaluation of the Registration Accuracy Using Monte Carlo Simulation

• DOI: 10.1007/s12021-012-9158-x
• Publication Date: 2012-08-18T03:45:03Z
• Authors: Berta Martí Fuster; Oscar Esteban; Xavier Planes; Pablo Aguiar; Cristina Crespo; Carles Falcon; Gert Wollny; Sebastià Rubí Sureda; Xavier Setoain; Alejandro F. Frangi; Maria J. Ledesma; Andrés Santos; Javier Pavía; Domènec Ros
• Keywords: Spect imaging; Image registration; Subtraction

Subtraction of Ictal SPECT Co-registered to MRI (SISCOM) is an imaging technique used localize the epileptogenic focus in patients with intractable partial epilepsy. The aim this study was determine accuracy registration algorithms involved SISCOM analysis using FocusDET, a new user-friendly application. To end, Monte Carlo simulation employed generate realistic studies. Simulated sinograms were reconstructed by Filtered BackProjection (FBP) algorithm and Ordered Subsets Expectation Maximization (OSEM) reconstruction method that included compensation for all degradations. Registration errors SPECT-SPECT SPECT-MRI evaluated comparing theoretical actual transforms. Patient studies well-localized epilepsy also assessment. Global including less than 1.2 mm on average, exceeding voxel size (3.32 mm) no case. Although images OSEM led lower FBP, differences after or FBP 0.2 average. This indicates correction degradations does not play major role process, thereby facilitating application methodology centers where implemented These findings together those obtained clinicians from via MRI, interictal ictal video-EEG, show FocusDET robust performing clinical practice.