GeodesicSlicer: a Slicer Toolbox for Targeting Brain Stimulation

• DOI: 10.1007/s12021-020-09457-9
• Publication Date: 2020-03-03T13:02:31Z
• Authors: F. Briend; E. Leroux; C. Nathou; N. Delcroix; S. Dollfus; O. Etard
• Keywords: Adult; Male; Correction factor; [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology; [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior; 3D slicer; 03 medical and health sciences; Target determination; Imaging, Three-Dimensional; 0302 clinical medicine; 3D Slicer; rTMS; Image Interpretation, Computer-Assisted; Humans; EEG; Neuronavigation; Depressive Disorder, Major; [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior; NIBS; [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology; [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences; Brain; Electroencephalography; Middle Aged; Magnetic Resonance Imaging; Transcranial Magnetic Stimulation; correction factor; target determination; Schizophrenia; Female; [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences; Algorithms; Software

NonInvasive Brain Stimulation (NIBS) is a potential therapeutic tool with growing interest, but neuronavigation-guided software and tools available for the target determination are mostly either expensive or closed proprietary applications. To address these limitations, we propose GeodesicSlicer, a customizable, free, and open-source NIBS therapy research toolkit. GeodesicSlicer is implemented as an extension for the widely used 3D Slicer medical image visualization and analysis application platform. GeodesicSlicer uses cortical stimulation target from either functional or anatomical images to provide functionality specifically designed for NIBS therapy research. The provided algorithms are tested and they are accessible through a convenient graphical user interface. Modules have been created for NIBS target determination according to the position of the electrodes in the 10-20 system electroencephalogram and calculating correction factors to adjust the repetitive Transcranial Magnetic Stimulation (rTMS) dose for the treatment. Two illustrative examples are processing with the module. This new open-source software has been developed for NIBS therapy: GeodesicSlicer is an alternative for laboratories that do not have access to neuronavigation system. The triangulation-based MRI-guided method presented here provides a reproducible and inexpensive way to position the TMS coil that may be used without the use of a neuronavigation system.