Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis

• DOI: 10.1007/s12028-020-01151-7
• Publication Date: 2020-12-11T15:05:04Z
• Authors: Julia K. Böhm; Helge Güting; Sophie Thorn; Nadine Schäfer; Victoria Rambach; Herbert Schöchl; Oliver Grottke; Rolf Rossaint; Simon Stanworth; Nicola Curry; Rolf Lefering; Marc Maegele; ; Cecilia Åkerlund; Krisztina Amrein; Nada Andelic; Lasse Andreassen; Audny Anke; Anna Antoni; Gérard Audibert; Philippe Azouvi; Maria Luisa Azzolini; Ronald Bartels; Pál Barzó; Romuald Beauvais; Ronny Beer; Bo-Michael Bellander; Antonio Belli; Habib Benali; Maurizio Berardino; Luigi Beretta; Morten Blaabjerg; Peter Bragge; Alexandra Brazinova; Vibeke Brinck; Joanne Brooker; Camilla Brorsson; Andras Buki; Monika Bullinger; Manuel Cabeleira; Alessio Caccioppola; Emiliana Calappi; Maria Rosa Calvi; Peter Cameron; Guillermo Carbayo...; Marco Carbonara; Simona Cavallo; Giorgio Chevallard; Arturo Chieregato; Giuseppe Citerio; Iris Ceyisakar; Hans Clusmann; Mark Coburn; Jonathan Coles; Jamie D. Cooper; Marta Correia; Amra Čović; Nicola Curry; Endre Czeiter; Marek Czosnyka; Claire Dahyot-Fiz...; Paul Dark; Helen Dawes; Véronique De Keyser; Vincent Degos; Francesco Della C...; Hugo den Boogert; Bart Depreitere; Đula Đilvesi; Abhishek Dixit; Emma Donoghue; Jens Dreier; Guy-Loup Dulière; Ari Ercole; Patrick Esser; Erzsébet Ezer; Martin Fabricius; Valery L. Feigin; Kelly Foks; Shirin Frisvold; Alex Furmanov; Pablo Gagliardo; Damien Galanaud; Dashiell Gantner; Guoyi Gao; Pradeep George; Alexandre Ghuysen; Lelde Giga; Ben Glocker; Jagoš Golubovic; Pedro A. Gomez; Johannes Gratz; Benjamin Gravesteijn; Francesca Grossi; Russell L. Gruen; Deepak Gupta; Juanita A. Haagsma; Iain Haitsma; Raimund Helbok; Eirik Helseth; Lindsay Horton; Jilske Huijben; Peter J. Hutchinson; Bram Jacobs; Stefan Jankowski; Mike Jarrett; Ji-yao Jiang; Faye Johnson; Kelly Jones; Mladen Karan; Angelos G. Kolias; Erwin Kompanje; Daniel Kondziella; Evgenios Koraropo...; Lars-Owe Koskinen; Noémi Kovács; Ana Kowark; Alfonso Lagares; Linda Lanyon; Steven Laureys; Fiona Lecky; Didier Ledoux; Rolf Lefering; Valerie Legrand; Aurelie Lejeune; Leon Levi; Roger Lightfoot; Hester Lingsma; Andrew I. R. Maas; Ana M. Castaño-León; Marc Maegele; Marek Majdan; Alex Manara; Geoffrey Manley; Costanza Martino; Hugues Maréchal; Julia Mattern; Catherine McMahon; Béla Melegh; David Menon; Tomas Menovsky; Ana Mikolic; Benoit Misset; Visakh Muraleedharan; Lynnette Murray; Ancuta Negru; David Nelson; Virginia Newcombe; Daan Nieboer; József Nyirádi; Otesile Olubukola; Matej Oresic; Fabrizio Ortolano; Aarno Palotie; Paul M. Parizel; Jean-François Payen; Natascha Perera; Vincent Perlbarg; Paolo Persona; Wilco Peul; Anna Piippo-Karja...; Matti Pirinen; Horia Ples; Suzanne Polinder; Inigo Pomposo; Jussi P. Posti; Louis Puybasset; Andreea Radoi; Arminas Ragauskas; Rahul Raj; Malinka Rambadagalla; Jonathan Rhodes; Sylvia Richardson; Sophie Richter; Samuli Ripatti; Saulius Rocka; Cecilie Roe; Olav Roise; Jonathan Rosand; Jeffrey V. Rosenfeld; Christina Rosenlund; Guy Rosenthal; Rolf Rossaint; Sandra Rossi; Daniel Rueckert; Martin Rusnák; Juan Sahuquillo; Oliver Sakowitz; Renan Sanchez-Porras; Janos Sandor; Nadine Schäfer; Silke Schmidt; Herbert Schoechl; Guus Schoonman; Rico Frederik Schou; Elisabeth Schwend...; Charlie Sewalt; Toril Skandsen; Peter Smielewski; Abayomi Sorinola; Emmanuel Stamatakis; Simon Stanworth; Robert Stevens; William Stewart; Ewout W. Steyerberg; Nino Stocchetti; Nina Sundström; Anneliese Synnot; Riikka Takala; Viktória Tamás; Tomas Tamosuitis; Mark Steven Taylor; Braden Te Ao; Olli Tenovuo; Alice Theadom; Matt Thomas; Dick Tibboel; Marjolein Timmers; Christos Tolias; Tony Trapani; Cristina Maria Tu...; Andreas Unterberg; Peter Vajkoczy; Shirley Vallance; Egils Valeinis; Zoltán Vámos; Mathieu van der Jagt; Gregory Van der S...; Joukje van der Naalt; Jeroen T. J. M. v...; Thomas A. van Essen; Wim Van Hecke; Caroline van Heugten; Dominique Van Praag; Thijs Vande Vyvere; Roel P. J. van Wijk; Alessia Vargiolu; Emmanuel Vega; Kimberley Velt; Jan Verheyden; Paul M. Vespa; Anne Vik; Rimantas Vilcinis; Victor Volovici; Nicole von Steinb...; Daphne Voormolen; Petar Vulekovic; Kevin K. W. Wang; Eveline Wiegers; Guy Williams; Lindsay Wilson; Stefan Winzeck; Stefan Wolf; Zhihui Yang; Peter Ylén; Alexander Younsi; Frederick A. Zeiler; Veronika Zelinkova; Agate Ziverte; Tommaso Zoerle
• Keywords: Neurointensive care; Glasgow Outcome Scale

Abstract Background Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated high rates of complications, unfavourable outcomes and mortality. The mechanism the development TBI-associated poorly understood. Methods This analysis, embedded prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise TBI. Emphasis was placed on acute phase following TBI, primary subgroups abnormal coagulation profile within 4 h admission, impact pre-injury anticoagulant and/or antiplatelet therapy. In order minimise confounding factors, isolated TBI (iTBI) ( n = 598) were selected for this analysis. Results Haemostatic disorders observed approximately 20% iTBI patients. a subgroup therapy had twice exacerbated as likely those without premedication. turn increased mortality outcome post-injury. A multivariate analysis identified several independent risk factors which present at hospital admission. Glasgow Coma Scale (GCS) less than or equal 8, base excess (BE) − 6, hypothermia hypotension significantly. Conclusion Consideration these enables early prediction stratification after thus guiding clinical management.