Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

• DOI: 10.1007/s12028-021-01260-x
• Publication Date: 2021-07-08T13:02:50Z
• Authors: Jan Claassen; Yama Akbari; Sheila Alexander; Mary Kay Bader; Kathleen Bell; Thomas P. Bleck; Melanie Boly; Jeremy Brown; Sherry H.-Y. Chou; Michael N. Diringer; Brian L. Edlow; Brandon Foreman; Joseph T. Giacino; Olivia Gosseries; Theresa Green; David M. Greer; Daniel F. Hanley; Jed A. Hartings; Raimund Helbok; J. Claude Hemphill; H. E. Hinson; Karen Hirsch; Theresa Human; Michael L. James; Nerissa Ko; Daniel Kondziella; Sarah Livesay; Lori K. Madden; Shraddha Mainali; Stephan A. Mayer; Victoria McCredie; Molly M. McNett; Geert Meyfroidt; Martin M. Monti; Susanne Muehlschl...; Santosh Murthy; Paul Nyquist; DaiWai M. Olson; J. Javier Provencio; Eric Rosenthal; Gisele Sampaio Silva; Simone Sarasso; Nicholas D. Schiff; Tarek Sharshar; Lori Shutter; Robert D. Stevens; Paul Vespa; Walter Videtta; Amy Wagner; Wendy Ziai; John Whyte; Elizabeth Zink; Jose I. Suarez
• Keywords: Neurointensive care; Persistent vegetative state; Coma (optics); Endotype; Deliverable

Abstract Coma and disorders of consciousness (DoC) are highly prevalent constitute a burden for patients, families, society worldwide. As part the Curing Campaign, Neurocritical Care Society partnered with National Institutes Health to organize symposium bringing together experts from all over world develop research targets DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, (6) large datasets. This proceedings paper presents actionable based on presentations discussions that occurred at conference. We summarize background, main gaps, overall goals, panel discussion approach, limitations challenges, deliverables were identified.