Euxanthone Attenuates Aβ1–42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy

• DOI: 10.1007/s12031-018-1175-2
• Publication Date: 2018-10-21T22:31:55Z
• Authors: Haicheng Yuan; Chuanwu Jiang; Jingde Zhao; Yunsheng Zhao; Yongbin Zhang; Yanqi Xu; Xiaoning Gao; Lingfei Guo; Yongji Liu; Kai Liu; Bo Xu; Gang Sun
• Keywords: Male; 0301 basic medicine; Amyloid beta-Peptides; Xanthones; Apoptosis; Hippocampus; PC12 Cells; Antioxidants; Peptide Fragments; Rats; 3. Good health; Rats, Sprague-Dawley; Oxidative Stress; 03 medical and health sciences; Neuroprotective Agents; Alzheimer Disease; Autophagy; Animals

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and in vitro. We found that euxanthone significantly attenuated Aβ1-42-induced memory and spatial learning dysfunction and also significantly reversed Aβ1-42-induced neuronal apoptosis and autophagy in the hippocampal region. Euxanthone also protected the neuroblastic PC12 cells against Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy. In conclusion, euxanthone exerts its neuroprotective effect against Aβ1-42 by inducing autophagy, indicating its potential therapeutic role in AD.