Lack of Pituitary Adenylate Cyclase–Activating Polypeptide (PACAP) Disturbs Callus Formation

• DOI: 10.1007/s12031-019-01448-z
• Publication Date: 2019-12-05T18:02:46Z
• Authors: Gergő Józsa; Balázs Dániel Fülöp; László Kovács; Bernadett Czibere; Vince Szegeczki; Tamás Kiss; Tibor Hajdú; Andrea Tamás; Zsuzsanna Helyes; Róza Zákány; Dóra Reglődi; Tamás Juhász
• Keywords: Neurochemistry; Callus

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a naturally secreted signaling peptide and has important regulatory roles in the differentiation of central nervous system its absence results disorders femur development. PACAP an function prevention oxidative stress or mechanical chondrogenesis but little known about bone regeneration. A new callus formation model was set to investigate role remodeling. Fracturing 5 mm distal from proximal articular surface tibia depth 0.5 mm. Reproducibility investigated with CT 3, 7, 21 days after operation. Absence did not alter alkaline phosphatase (ALP) activation KO healing process. In developing callus, expression collagen type I increased wild-type (WT) mice decreased end Expression elements BMP disturbed mice, as morphogenic protein 4 (BMP4) 6 showed early reduction However, elevated Smad1 demonstrated mice. Our indicate that show various signs suggest compensatory fine tuning effects proper