Cancer/testis antigen expression and co-expression patterns in gastroesophageal adenocarcinoma

• DOI: 10.1007/s12032-024-02475-6
• Publication Date: 2024-08-14T17:01:50Z
• Authors: Sukumar Kalvapudi; Akhil Goud Pachim...; R. J. Seager; Jeffrey Conroy; Sarabjot Pabla; Sarbajit Mukherjee
• Keywords: Hematology; Expression (computer science)

Gastroesophageal adenocarcinoma (GEAC) poses a significant challenge due to its poor prognosis and limited treatment options. Recently, Cancer/testis antigens (CTAs) have emerged as potential therapy targets their high expression in tumor cells immunogenic nature. We aimed explore the co-expression of CTAs GEAC. analyzed 63 GEAC patients initially validated our findings 329 from The Cancer Genome Atlas (TCGA) database. CTA was measured after RNA sequencing, while clinical information, including survival outcomes details, collected an institutional Co-expression patterns among were determined using Spearman correlation analysis. majority study cohort male (87%), Caucasian (94%), had stage IV disease (64%). highly prevalent, ranging 58 19%. MAGE gene family showed highest expression, consistent across both cohorts. matrix revealed distinct cluster significantly co-expressed genes, MAGEA3, NY-ESO-1, others (0.27 ≤ r 0.73). Survival analysis that individual associated with poorer not receiving immunotherapy showing for improved those undergoing immunotherapy, although these lacked robust reliability. Our provides comprehensive characterization strong like MAGE, GAGE suggests therapies targeting multiple simultaneously. Further research, prospective trials, is warranted assess prognostic value suitability therapeutic targets.