Electroacupuncture Alleviates Hyperalgesia and Anxiety-Like Behaviors in Pain Memory Model Rats Through Activation of GABAergic Neurons and GABA Receptor in the Rostral Anterior Cingulate Cortex

• DOI: 10.1007/s12035-024-03986-z
• Publication Date: 2024-02-08T09:02:26Z
• Authors: Jing Sun; Chi Zhang; Yifang Wang; Siqi Xiao; Haiju Sun; Zhiyuan Bian; Zui Shen; Xiaofen He; Jianqiao Fang; Xiaomei Shao
• Keywords: Cingulate cortex

Recent studies have confirmed that pain memory is often accompanied by negative emotions. Electroacupuncture (EA) can block the retrieval of painful memories, thereby alleviating associated behaviors. However, underlying mechanism poorly understood. This study revealed effect EA on memory-induced behaviors related to mediation GABAergic neuron activity and GABA receptor expression in rostral anterior cingulate cortex (rACC). Previous shown rACC a crucial area for regulating nociceptive emotions models. The neurons receptors are largely involved sensation effects. relationships among memory, not been investigated. In this study, we established model via secondary plantar cross-injection carrageenan treatment. Using chemogenetic methods behavioral assessments emotion, found early excitation blocked recall memories reduced anxiety-like rats. Furthermore, pharmacological