New co-crystal and salt form of sulfathiazole with carboxylic acid and amide

• DOI: 10.1007/s12039-014-0698-5
• Publication Date: 2014-11-03T11:51:49Z
• Authors: RANITA SAMANTA; SHIPRA KANAUJIA; C MALLA REDDY
• Keywords: 01 natural sciences; 0104 chemical sciences; 3. Good health

One co-crystal and one salt of an antibacterial drug sulfathiazole with 4-aminobenzamide and 2,4-dinitrobenzoic acid have been synthesized. These new forms are characterized by single crystal X-ray diffraction, infrared spectroscopy, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). In solid state, sulfathiazole preferentially adopts the imidine tautomeric form.