Study on Effects of Sublingual Immunotherapy in Allergic Rhinitis Patients

• DOI: 10.1007/s12070-022-03366-w
• Publication Date: 2022-12-29T12:03:45Z
• Authors: Keval Patel; Nandini Gupta; Bela J. Prajapati; Arpit Prajapati; Shweta Sharma; Dhara Rathava
• Keywords: Slit; Sublingual Immunotherapy; Tolerability; Nasal congestion; Sublingual administration; Allergen Immunotherapy

Allergic Rhinitis is one of the most common allergic disease and characterized by sneezing, rhinorrhea, nasal congestion and nasopharyngeal itching. The initial management includes pharmacological treatment and the patients who are refractory to pharmacological treatment are then reffered for immunotherapy. SLIT has been widely used for treatment of allergic rhinitis and has proven its clinical efficacy. The objective of the present study was to assess the clinical effects, safety and tolerability of sublingual immunotherapy (SLIT) among the patients suffering from allergic rhinitis. The study was conducted from Aug 2018 to April 2021 and 40 patients with convincing history, positive skin prick test to one or more allergen extracts were recruited. SLIT was conducted with antigens (mix), namely dust mites, tree pollens, grass pollens and weed pollens in patients of allergic rhinitis for 1 year. There was significant improvement in quality of life and symptoms severity(Nasal and Non-Nasal) from base line to end of 1 year. SLIT lowers the total IgE, absolute eosinophilic count and medication requirement. Sublingual Immunotherapy for specific allergens decreases clinical symptoms in patients with allergic rhinitis and sensitivity to multiple allergen.