Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China

• DOI: 10.1007/s12072-020-10075-5
• Publication Date: 2020-10-07T11:03:01Z
• Authors: Ming Wang; Weiming Yan; Weipeng Qi; Di Wu; Lin Zhu; Weina Li; Xiaojing Wang; Ke Ma; Ming Ni; Dong Xu; Hongwu Wang; Guang Chen; Haijing Yu; Hongfang Ding; Mingyou Xing; Meifang Han; Xiaoping Luo; Tao Chen; Wei Guo; Dong Xi; Qin Ning
• Keywords: White blood cell

Abstract Background Coronavirus disease 2019 (COVID-19) has rapidly become a major international public health concern. This study was designed to evaluate the clinical characteristics and risk factors of COVID-19-associated liver injury. Methods A fraction 657 COVID-19 patients were retrospectively analyzed. Clinical laboratory data derived from electronic medical records compared between with or without Multivariate logistic regression method used analyze for Results Among patients, 303 (46.1%) had injury higher rate in severe/critically ill [148/257 (57.6%)] than those moderate cases [155/400 (38.8%)]. The incidence much male [192/303 (63.4%)] female [111/303 (36.6%)], severe/critical [148/303 (48.8%)] percutaneous oxygen saturation ≤ 93% [89/279 (31.9%)] peak body temperature ≥ 38.5 °C [185/301 (61.5%)] on admission. Liver injury-related inflammations included increased white blood cells, neutrophils decreased lymphocytes. More serum IL-2R, TNFα, ferritin, hsCRP, PCT, ESR, γ-GT, LDH. analysis revealed that increasing odds related male, hsCRP (≥ 10 mg/L), neutrophil-to-lymphocyte ratio (NLR) 5). Moreover, more deceased (14/82 (17%)) significantly elevated TBIL discharged [25/532 (4.7%)]. Conclusion is common complication patients. potential include NLR score. close monitor function should be warned especially individuals.