SEOM clinical guidelines for hereditary cancer

• DOI: 10.1007/s12094-011-0701-2
• Publication Date: 2011-08-19T05:30:18Z
• Authors: Begoña Graña; Enrique Lastra; Gemma Llort; Joan Brunet; Dolores Isla
• Keywords: Adult; Male; Ovarian Neoplasms; Genes, BRCA2; Genes, BRCA1; Breast Neoplasms; Middle Aged; Medical Oncology; Colorectal Neoplasms, Hereditary Nonpolyposis; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Neoplasms; Biomarkers, Tumor; Humans; Female; Societies, Medical; Neoplasm Staging

Research in genetics has facilitated the identification of highly penetrant genes responsible for a large number of diseases. In the oncology field, genetic counselling and gene testing are focused on the two most common syndromes in familial cancer: hereditary breast and ovarian cancer syndrome (HBOC) and hereditary non-polyposis colorectal cancer or Lynch syndrome (LS). The objective of this guideline in hereditary cancer is to summarise the current state of knowledge and make recommendations in the areas of diagnosis, prevention and treatment of hereditary cancer.