Are Interleukin-6, Body Mass Index and Atopy Crucial in Infantile Intussusception?

• DOI: 10.1007/s12098-010-0218-7
• Publication Date: 2010-09-29T09:10:55Z
• Authors: Bilge Karabulut; Derya Erdoğan; İlknur Bostancı; Ufuk Önde; Ayşe Esra Karakoç
• Keywords: Hypersensitivity, Immediate; Inflammation; Male; 2. Zero hunger; Turkey; Interleukin-6; Matched-Pair Analysis; Infant; Body Mass Index; 3. Good health; 03 medical and health sciences; Logistic Models; 0302 clinical medicine; Case-Control Studies; Humans; Female; Obesity; Intussusception; Biomarkers

To determine the role of inflammation related to body mass index (BMI) and atopy in the etiology of idiopathic intussusception (IS) which is seen more frequently in obese children and which is considered to increase in the allergy season.The study comprised a study group consisting of 22 infants with IS and a control group consisting of 20 healthy infants with age and BMI matched. In both groups, gender, weight, height, month of birth, month of admittance (allergy season) of each infant were recorded. Information regarding whether or not the child had any skin rash, atopy, oral allergy syndrome, and whether or not the patient had been fed cow's milk and breast milk was recorded. Hemoglobin (Hb) levels, white blood cell (WBC) and eosinophil counts, interleukin-6 (IL-6) levels and allergy panel were studied in all patients. Additionally, cross reactive protein (CRP) and blood urea nitrogen (BUN) levels were determined in the study group. During statistical comparison p < 0.05 was considered statistically significant.Mean IL-6 levels in the control and study groups were 1.59 ± 0.15 pg/ml and 4.12 ± 5.04 pg/ml, respectively. IL-6 levels were statistically different between each groups and between cases with barium reduction and cases reduced manually by laparotomy within the study group. Both groups were similar statistically with regard to the others parameters. No atopy was detected by allergy panel. When binary logistic regression analysis with the cut-off value of IL-6 set as 1.6 pg/ml was applied to all data, statistically significant values were obtained only when the case was in the study group and when CRP levels were increased (p = 0.05 and p = 0.001, respectively).We demonstrated that IL-6 levels are increased in the study group, especially in the operated patients, however, that high BMI and atopy have no effects on this fact and that atopy is not associated with IS in the clinical study.