Immunohistochemical Expression of p16, p21, p27 and Cyclin D1 in Oral Nevi and Melanoma

• DOI: 10.1007/s12105-012-0334-y
• Publication Date: 2012-02-04T07:22:02Z
• Authors: Bruno Augusto Ben...; Jorge Esquiche León; Román Carlos; Wilson Delgado-Az...; Adalberto Mosqued...; Oslei Paes de Alm...
• Keywords: Adult; Cyclin-Dependent Kinase Inhibitor p21; Male; 0301 basic medicine; Adolescent; cyclin dependent kinase inhibitor 1A; cyclin dependent kinase inhibitor 1B; Young Adult; 03 medical and health sciences; 0302 clinical medicine; mouth tumor; Biomarkers, Tumor; Humans; Cyclin D1; Melanoma; Nevus; Cyclin-Dependent Kinase Inhibitor p16; https://purl.org/pe-repo/ocde/ford#3.02.21; Aged; Oral nevi; Middle Aged; Immunohistochemistry; Oral melanoma; Neoplasm Proteins; 3. Good health; Tumor Markers, Biological; CCND1 protein, |CDKN1A protein, |Cell cycle; P16 protein, |tumor protein; tumor marker; Female; Mouth Neoplasms; biosynthesis; metabolism; Cyclin-Dependent Kinase Inhibitor p27

The acquisition of abnormalities at G1/S is considered a crucial step in the genesis and progression of melanoma. The expression of cell cycle regulators has also been used in various neoplasms as an adjunct to diagnosis. The aim of this study was to compare the expression of p16, p21, p27 and cyclin D1 in oral nevi and melanomas. Expression of these cell cycle regulatory proteins was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas. p16 and p27 were highly expressed in intramucosal nevi, whereas p21 and cyclin D1 expression was higher in oral melanomas. The results indicate that p21 and cyclin D1 may be involved in the development of oral melanomas, and eventually they may be useful in the differential diagnoses of oral benign and malignant melanocytic lesions.