Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

• DOI: 10.1007/s12105-022-01459-0
• Publication Date: 2022-05-27T09:03:02Z
• Authors: Ibrahim Alsanie; Shahad Rajab; Hannah Cottom; Oluyori Adegun; Reshma Agarwal; Amrita Jay; Laura Graham; Jacqueline James; A. William Barrett; Willie van Heerden; Mariano de Vito; Alessandra Canesso; Akinyele Olumuyiw...; Abdul-Warith Olai...; Oluseyi Folake Ajayi; Mark Chukwuemeka ...; Chukwubuzor Udokw...; Olufemi Gbenga Om...; Efetobo Victor Or...; Merva Soluk-Tekkesin; Ibrahim O. Bello; Ahmed Qannam; Wilfredo Gonzalez; Maria Eduarda Pér...; Alan Roger Santos...; Pablo Agustin Vargas; Eu-Wing Toh; Syed Ali Khurram
• Keywords: SDG-03: Good health and well-being; Granular Cell Tumor: Clinical and Pathological Characteristics; Salivary Gland Tumors and Carcinomas; Epidemiology; 610; Adenoid cystic carcinoma; Pathology and Forensic Medicine; Cohort Studies; Head and neck; 03 medical and health sciences; 0302 clinical medicine; Pleomorphic adenoma; Salivary gland tumours (SGT); Multicentre research study; Health Sciences; Salivary gland tumours; Pathology; Site distribution; Humans; Salivary Gland Tumors; Tumors of the Ear and Temporal Bone; Salivary gland neoplasms; Salivary gland; Original Paper; Incidence (geometry); Physics; Carcinoma; Optics; Histological diagnosis; Salivary Gland Neoplasms; 3. Good health; Oncology; Otorhinolaryngology; Medicine; Demographics; Female; Surgery; Mucoepidermoid carcinoma; Parotid gland

Abstract Background Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only.

Methods This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. The analysed data included age, gender, location and histological diagnosis from fifteen centres covering the majority of the world health organisation (WHO) geographical regions between 2006 and 2019.

Results A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed. The majority (68%) of the SGT presented in major and 32% in the minor glands. The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. Pleomorphic adenoma (70%), and Warthin’s tumour (17%), were the most common benign tumours whereas mucoepidermoid carcinoma (26%) and adenoid cystic carcinoma (17%) were the most frequent malignant tumours.

Conclusions This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. These findings should serve as a baseline for future studies evaluating the epidemiological landscape of these tumours.