Effect of respiratory motion on cardiac defect contrast in myocardial perfusion SPECT: a physical phantom study

• DOI: 10.1007/s12149-019-01335-y
• Publication Date: 2019-01-25T00:48:03Z
• Authors: Matti J. Kortelainen; Tuomas M. Koivumäki; Marko J. Vauhkonen; Mikko A. Hakulinen
• Keywords: Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Phantoms, Imaging; Movement; Respiration; Myocardial Perfusion Imaging; Heart; 03 medical and health sciences; 0302 clinical medicine; Image Processing, Computer-Assisted; Original Article; Artifacts

Correction for respiratory motion in myocardial perfusion imaging requires sorting of emission data into windows where the intra-window is assumed to be negligible. However, it unclear how much acceptable. The aim this study was determine an optimal value residual motion. A custom-designed cardiac phantom created and imaged with a standard dual-detector SPECT/CT system using Tc-99m as radionuclide. Projection images were generated from list-mode simulating blur several magnitudes 0 (stationary phantom) 20 mm. Cardiac defect contrasts six anatomically different locations, well apex, anterior, inferior, septal lateral walls, measured at each magnitude. Stationary compared motion-blurred data. Two physicians viewed evaluated differences visibility perfusion. Significant associations observed between anterior inferior walls Defect found decline function motion, but magnitude depended on location shape defect. Defects located near apex lost contrast more rapidly than those wall. decreased by less 5% every when 2 mm or less. According visual evaluation, there if greater 1 mm, 9 Intra-window should limited effectively correct SPECT.