18F-FDG PET/CT as predictive and prognostic factor in esophageal cancer treated with combined modality treatment

• DOI: 10.1007/s12149-022-01733-9
• Publication Date: 2022-03-11T14:02:52Z
• Authors: Marco Krengli; Eleonora Ferrara; Riccardo Guaschino; Erinda Puta; Lucia Turri; Ilaria Luciani; Gian Mauro Sacchetti; Pierfrancesco Franco; Marco Brambilla
• Keywords: Modality (human–computer interaction); PET-CT; Treatment modality

[18F] fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG-PET/CT) is used for diagnosis, staging, response assessment and prognosis prediction in different tumors, but its role esophageal cancer still debated. The aim of this study was to evaluate the semiquantitative baseline PET parameters as possible prognostic predictive factors a series carcinomas treated with combined modalities.43 patients carcinoma were chemoradiotherapy (CRT) followed by surgery 20 cases underwent pre-treatment 18F-FDG-PET/CT. Semiquantitative evaluated including Standardized Uptake Value (SUVmax e SUVmean), Metabolic Tumor Volume (MTV) Total Lesion Glycolysis (TLG) isocontour 41 50%. Further variables analyzed gender, primary tumor site, histological type, use surgery, achievement radical resection type chemotherapy regimen. correlation all treatment response, loco-regional control (LR), Overall survival (OS) Disease-Free Survival (DFS) evaluated.SUVmax, SUVmean50 SUVmean41 significantly higher node-positive squamous cell carcinomas. With respect factors, MTV found be correlated OS: MTV41 < 11.32 cm3 MTV50 8.07 (both p values = 0.04) showed better 3-year OS rates (33 vs. 20%). predicting (R0) 0.01).Pre-treatment significant OS, together R0 cancers multimodal therapies.