A case of mistaken identity: HSPs are no DAMPs but DAMPERs

• DOI: 10.1007/s12192-011-0311-5
• Publication Date: 2011-12-03T11:30:44Z
• Authors: Willem van Eden; Rachel Spiering; Femke Broere; Ruurd van der Zee
• Keywords: Identification

Until recently, the immune system was seen solely as a defense with its primary task being elimination of unwanted microbial invaders. Currently, however, functional significance has obtained much wider perspective, to include among others maintenance and restoration homeostasis following tissue damage. In this latter aspect, there is growing interest in identification molecules involved, such so-called danger or damage-associated molecular patterns (DAMPs), also called alarmins. Since heat shock proteins are archetypical produced under stressful conditions, damage inflammation, they frequently mentioned prime examples DAMPs (Bianchi, J Leukoc Biol 81:1-5, 2007; Kono Rock, Nat Rev Immunol 8:279-289, 2008; Martin-Murphy et al., Toxicol Lett 192:387-394, 2010). See for instance recent review (Chen Nunez, Science 298:1395-1401, Contrary description, we recently presented some arguments against role protein (Broere 11:565-c1, 2011). With perspective reflection article, hope elaborate on debate provide additional thoughts further ignite discussion critical evolving issue.