Polymorphism of Promoter Region of TNFRSF1A Gene (−610 T > G) as a Novel Predictive Factor for Radiotherapy Induced Oral Mucositis in HNC Patients

• DOI: 10.1007/s12253-017-0227-1
• Publication Date: 2017-04-11T12:00:09Z
• Authors: Anna Brzozowska; Tomasz Powrózek; Iwona Homa-Mlak; Radosław Mlak; Marzanna Ciesielka; Paweł Gołębiowski; Teresa Małecka-Ma...
• Keywords: Mucositis; SNP

Every year, about 650 thousand new cases of Head and Neck Cancer (HNC) are diagnosed globally. Apart from surgery, radiotherapy (RTH), chemotherapy (CHT) or its combination is used in the treatment HNC. One most frequent complications and, at same time, limitations RTH oral mucositis (OM). Proinflammatory cytokines (including TNF-α) play a key role development OM. Genetic alterations, i.e. single nucleotide polymorphisms (SNPs) within genes encoding for receptors TNF (ie. TNFRSF1A) may change their function. The aim this study was to investigate relationship between polymorphism TNFRSF1A occurrence severity acute reaction after HNC patients. Data 58 patients (stages I-IV) were analyzed. All them irradiated using IMRT technique with doses 50-70Gy. Oral (OM) evaluated according RTOG/EORTC guidelines. DNA isolated whole blood genotypes determined by sequencing method. Patients TT GT genotype demonstrated higher risk manifestation grade 3 OM 5th week (p=0.041; OR=9.240; 95% CI: 1.101–77.581) compared GG carriers. Similarly, high T allele presence noted 6th (p=0.030; OR=10.50; 95%CI:1.257–87.690) 7th (p=0.008; OR=5.625; 1.584–19.975) homozygote. Our results indicate an association SNP (rs4149570) gene more severe related radiation therapy