Novel immune checkpoints beyond PD-1 in advanced melanoma

• DOI: 10.1007/s12254-021-00699-0
• Publication Date: 2021-03-31T14:03:02Z
• Authors: Nina Zila; Christoph Hoeller; Verena Paulitschke
• Keywords: Immune checkpoint

Summary In malignant diseases, targeting of immune checkpoints successfully changed the therapeutic landscape and helped to unleash anti-tumor T cell responses, resulting in durable clinical outcomes, but only up 50% patients. The success these therapies need overcome intrinsic acquired therapy resistance stimulated research identify new pathways targets. Numerous trials are currently evaluating novel checkpoint inhibitors or recently developed strategies like modulating tumor microenvironment, mostly combination with approved therapies. This short review briefly discusses promising targets, still under investigation, chance realize application foreseeable future.