Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice

• DOI: 10.1007/s12264-020-00473-y
• Publication Date: 2020-02-24T12:06:58Z
• Authors: Xiang Feng; Hui-Ying Zhao; Yu-Jin Shao; Hui-Fang Lou; Li-Ya Zhu; Shumin Duan; Yan-Qin Yu
• Keywords: Sleep; Social defeat

Abstract Social defeat stress (SDS) plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression. Sleep is generally considered to involve recovery brain from prior experience during wakefulness altered after acute SDS. However, effect SDS on sleep/wake behavior mice varies between studies. In addition, whether sleep changes response contribute not well established. Here, we first investigated effects states active period mice. Our results showed that total time (time rapid eye-movement [REM] non-REM [NREM] sleep) increased NREM mainly 3 h SDS, while REM at later time. Then, demonstrated had an anxiolytic benefit Mice deprived for 1 or remained highly anxious state, with ad libitum rapidly faded away. Altogether, our findings suggest sleep, indicate potential therapeutic strategy anxiety.