The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior

• DOI: 10.1007/s12264-023-01073-2
• Publication Date: 2023-05-31T04:16:44Z
• Authors: Jing Liu; Dechen Liu; Xiaotian Pu; Kexin Zou; Taorong Xie; Yaping Li; Haishan Yao
• Keywords: Human physiology; Pain medicine

The secondary motor cortex (M2) encodes choice-related information and plays an important role in cue-guided actions. M2 neurons innervate the dorsal striatum (DS), which also contributes to decision-making behavior, yet how modulates signals DS influence perceptual is unclear. Using mice performing a visual Go/No-Go task, we showed that inactivating projections impaired performance by increasing false alarm (FA) rate reward-irrelevant No-Go stimulus. choice signal of correlated with behavioral performance, inactivation projecting reduced DS. By measuring manipulating responses direct or indirect pathway striatal defined inputs, found exhibited shorter response latency stimulus, their early increased FA rate. These results demonstrate M2-to-DS crucial for suppressing inappropriate decision behavior.