Metabolic Diseases Downregulate the Majority of Histone Modification Enzymes, Making a Few Upregulated Enzymes Novel Therapeutic Targets—“Sand Out and Gold Stays”
0303 health sciences
Gene Expression Profiling
Acetylation
Methylation
Gene Expression Regulation, Enzymologic
Enzymes
3. Good health
Histone Code
Histones
Mice
03 medical and health sciences
Metabolic Diseases
Databases, Genetic
Animals
Data Mining
Humans
RNA, Messenger
Oligonucleotide Array Sequence Analysis
DOI:
10.1007/s12265-015-9664-y
Publication Date:
2016-01-08T09:49:17Z
AUTHORS (12)
ABSTRACT
To determine whether the expression of histone modification enzymes is regulated in physiological and pathological conditions, we took an experimental database mining approach pioneered in our labs to determine a panoramic expression profile of 164 enzymes in 19 human and 17 murine tissues. We have made the following significant findings: (1) Histone enzymes are differentially expressed in cardiovascular, immune, and other tissues; (2) our new pyramid model showed that heart and T cells are among a few tissues in which histone acetylation/deacetylation, and histone methylation/demethylation are in the highest varieties; and (3) histone enzymes are more downregulated than upregulated in metabolic diseases and regulatory T cell (Treg) polarization/ differentiation, but not in tumors. These results have demonstrated a new working model of "Sand out and Gold stays," where more downregulation than upregulation of histone enzymes in metabolic diseases makes a few upregulated enzymes the potential novel therapeutic targets in metabolic diseases and Treg activity.
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