Comparative Quantification of Arterial Lipid by Intravascular Photoacoustic-Ultrasound Imaging and Near-Infrared Spectroscopy-Intravascular Ultrasound

• DOI: 10.1007/s12265-018-9849-2
• Publication Date: 2018-11-28T10:06:39Z
• Authors: Ayeeshik Kole; Yingchun Cao; Jie Hui; Islam A. Bolad; Mouhamad Alloosh; Ji-Xin Cheng; Michael Sturek
• Keywords: Intravascular Ultrasound; Ex vivo; Photoacoustic Spectroscopy

Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo ex IVPA-US iliac arteries Ossabaw swine metabolic syndrome (MetS) lean investigate sensitivity for early-stage atherosclerosis. repeated NIRS-IVUS histology. Both showed significantly greater lipid MetS vs. swine, but only localized as perivascular. To late-stage atherosclerosis, we a human coronary artery Two advanced fibroatheromas were identified, agreement between IVPA-measured area NIRS-derived content. As confirmed histologically, has content similar provides additional depth resolution, enabling quantification localization cores within plaques.