Comparative Quantification of Arterial Lipid by Intravascular Photoacoustic-Ultrasound Imaging and Near-Infrared Spectroscopy-Intravascular Ultrasound
Male
0301 basic medicine
Swine
Intravascular imaging
Lipid core plaque
Iliac Artery
Photoacoustic Techniques
03 medical and health sciences
Near-infrared spectroscopy
Predictive Value of Tests
Animals
Humans
Ultrasonography, Interventional
Metabolic Syndrome
Spectroscopy, Near-Infrared
Perivascular adipose tissue
Reproducibility of Results
Middle Aged
Atherosclerosis
Lipids
Plaque, Atherosclerotic
3. Good health
Disease Models, Animal
Early Diagnosis
Swine, Miniature
Original Article
Female
Photoacoustic imaging
DOI:
10.1007/s12265-018-9849-2
Publication Date:
2018-11-28T10:06:39Z
AUTHORS (7)
ABSTRACT
Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo and ex vivo IVPA-US imaging of the iliac arteries of Ossabaw swine with metabolic syndrome (MetS) and lean swine to investigate sensitivity for early-stage atherosclerosis. We repeated imaging ex vivo with NIRS-IVUS for comparison to IVPA-US and histology. Both modalities showed significantly greater lipid in MetS vs. lean swine, but only IVPA-US localized the lipid as perivascular. To investigate late-stage atherosclerosis, we performed ex vivo IVPA-US imaging of a human coronary artery with comparison to NIRS-IVUS and histology. Two advanced fibroatheromas were identified, with agreement between IVPA-measured lipid area and NIRS-derived lipid content. As confirmed histologically, IVPA-US has sensitivity to detect lipid content similar to NIRS-IVUS and provides additional depth resolution, enabling quantification and localization of lipid cores within plaques.
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CITATIONS (14)
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