Synthesis and anti-platelet activity of obovatol derivatives

• DOI: 10.1007/s12272-011-0708-9
• Publication Date: 2011-08-02T07:18:40Z
• Authors: Jae-Hwan Kwak; Seul Lee; Eun-Seok Park; Jin-Kyung In; Jiho Song; Young Jin Kim; Nam Song Choi; Heesoon Lee; Yeo-Pyo Yun; Jin Tae Hong; Young-Shin Kwak; Kyung Hoon Min; Jae-Kyung Jung
• Keywords: 0303 health sciences; Arachidonic Acid; Dose-Response Relationship, Drug; Platelet Aggregation; Phenyl Ethers; Biphenyl Compounds; Antineoplastic Agents; Platelet Activation; 3. Good health; Structure-Activity Relationship; 03 medical and health sciences; Alcohols; Animals; Collagen; Rabbits; Platelet Aggregation Inhibitors

Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.