Decumbenone C, a new cytotoxic decaline derivative from the marine fungus Aspergillus sulphureus KMM 4640

• DOI: 10.1007/s12272-012-1007-9
• Publication Date: 2012-11-08T14:54:01Z
• Authors: Olesya I. Zhuravleva; Shamil Sh. Afiyat...; Olesya S. Vishchuk; Vladimir A. Denis...; Natalya N. Slinkina; Olga F. Smetanina
• Keywords: Derivative (finance)

A new decaline derivative, decumbenone C (1) along with four known compounds, decumbenones A (2) and B (3), diorcinol (4), and brevianamide F (5) were isolated from the marine fungus Aspergillus sulphureus KMM 4640. Decumbenone C shows potent cytotoxic activity against SK-MEL-5 human melanoma cells with IC(50) values of 0.9 μM.