Diphenyl derivatives from coastal saline soil fungus Aspergillus iizukae

• DOI: 10.1007/s12272-014-0371-z
• Publication Date: 2014-03-25T21:57:51Z
• Authors: Desheng Liu; Ling Yan; Liying Ma; Yuling Huang; Xiaohong Pan; Weizhong Liu; Zhihua Lv
• Keywords: Models, Molecular; Antibiotics, Antineoplastic; Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Biphenyl Compounds; Molecular Conformation; HL-60 Cells; 15. Life on land; 01 natural sciences; 0104 chemical sciences; Aspergillus; X-Ray Diffraction; Cell Line, Tumor; Fermentation; Humans; Spectrophotometry, Ultraviolet; Drug Screening Assays, Antitumor; Soil Microbiology

Two new diphenyl derivatives, named iizukines A (1) and B (2), along with nine known compounds were isolated from coastal saline soil derived fungus Aspergillus iizukae. The structures were determined by extensive spectroscopic analysis. Their cytotoxicities were preliminarily evaluated on HL-60, BEL-7402 and A-549 cell lines by the MTT assay.