Boron doped graphdiyne: A metal-free peroxidase mimetic nanozyme for antibacterial application

• DOI: 10.1007/s12274-021-3685-4
• Publication Date: 2021-08-12T15:02:47Z
• Authors: Xuelong Bi; Qiang Bai; Lina Wang; Fanglin Du; Manhong Liu; William W. Yu; Siheng Li; Jiaqiang Li; Zhiling Zhu; Ning Sui; Jin Zhang
• Keywords: Nanosheet; Nanomaterials

The abuse of conventional antibiotics leads to increasing bacterial resistance. Nanozyme is a new kind of ultra-efficient and safe nanomaterial with intrinsic enzyme-like activities, showing remarkable potential as a next generation nanobactericide. Graphdiyne (GDY) is a burgeoning two-dimensional (2D) carbon allotrope with intriguing physicochemical properties, holding a great promise as a metal-free nanozyme. In this study, a boron doped GDY nanosheet (B-GDY) was constructed to simulate the performance of peroxidase (POD). By promoting the decomposition of H2O2 to produce reactive oxygen species (ROS), the bactericidal efficacies against both Gram-positive and Gram-negative bacteria were substantially enhanced attributed to the extremely high catalytic activity of B-GDY. In-depth density functional theory (DFT) calculations illuminate that doping of boron can introduce more active B-defect sites as well as lower Gibbs free energy during the H2O2 decomposition reaction. Notably, B-GDY contributes to significant wound healing and excellent biocompatibility, reducing the biological burden. The design of this nanozyme opens a new avenue for the development of alternative antibiotics.