Evaluation of Bone Marrow Findings of COVID-19 by Minimally Invasive Autopsies: A Single Tertiary Care Centre Experience from India

• DOI: 10.1007/s12288-021-01489-8
• Publication Date: 2021-09-20T04:02:36Z
• Authors: Abhishek Purohit; Shruti Vaswani; Vikarn Vishwajeet; Deepak Kumar; Parag Vijayvergiya; Swapnil Tripathi; Tanuj Kanchan; Nikhil Kothari; Naveen Dutt; Poonam Elhence; Vijayalakshmi Nag; Pradeep Bhatia; Mahendra K. Garg; Sanjeev Misra
• Keywords: Tertiary care; Bone marrow aspirate

The 2019 novel coronavirus (2019-nCoV) originated in Wuhan City of China. In India, first confirmed case disease (COVID-19) was reported on January 30, 2020 and India is presently hit by second wave COVID-19. aim the present study to evaluate bone marrow findings COVID-19 minimally invasive autopsies aid understanding pathophysiology disease. This prospective conducted at tertiary care centre Western Rajasthan. After obtaining approval from Institute's ethics committee consent next kins, were 37 deceased patients within an hour after death. tissue specimens processed with standard biosafety measures. Electronic medical records reviewed retrospectively patients' clinical details results laboratory investigations noted. this study, biopsies collected autopsies. Mean age these cases 61.8 years male: female ratio 2.36. Comorbidities observed 25 (67.5%) all cases. Histopathological analysis revealed hypercellular, normocellular hypocellular 5, 5 respectively (two inadequate). There marked interstitial prominence histiocytes 24 (68.5%) Out these, evidence haemophagocytosis 14 (40%) cases, increase haemosiderin laden macrophages 20 (57.1%) plasma cells 28 (80%) attempted fill gap dearth literature our country autopsy studies highlighting findings. data support development secondary haemophagocytic lymphocytosis