Papaverine adjuvant therapy for microcirculatory disturbance in severe ulcerative colitis complicated with CMV infection: a case report

• DOI: 10.1007/s12328-019-00974-y
• Publication Date: 2019-04-04T05:58:37Z
• Authors: Yu Tian; Yue Zheng; Jinpei Dong; Jixin Zhang; Huahong Wang
• Keywords: Mesalazine

Ulcerative colitis has hypercoagulable state and high risk of thrombosis; so mucosal disturbance microcirculation may be mediate amplify the inflammation ulcerative colitis. A 56-year-old female patient was admitted in hospital for discontinuously mucous bloody stool more than 1 year. determined after colonoscopy pathologic examination. Mesalazine effective during year, but her symptoms recurred three times due to bad compliance. One month before admission, had severe recurrence mesalazine withdrawal. At this time, result quantitative fluorescence PCR colonic histic CMV-DNA 1.6 × 104 copies/mL positive, CMV accompanied. After 4 weeks ganciclovir 6 usage nutrition support, diarrhea abdominal cramp did not improve; frequency twenty a day. Probe-based confocal laser endomicroscopy revealed local disturbance. Papaverine 90-mg slow drip at least 10 h day added. The dramatically disappeared 3 days papaverine treatment. yellow mushy 2–3 Pathological findings showed diffuse submucosal hemorrhage transparent thrombosis capillaries. Treatment microcirculatory UC is promising adjuvant therapy. Confocal an method judgment.