Impact of respiratory gating and ECG gating on 18F-FDG PET/CT for cardiac sarcoidosis

• DOI: 10.1007/s12350-023-03236-0
• Publication Date: 2023-03-14T22:02:30Z
• Authors: Kohei Hanaoka; Shota Watanabe; Daisuke Morimoto-...; Hayato Kaida; Takahiro Yamada; Masakazu Yasuda; Yoshitaka Iwanaga; Gaku Nakazawa; Kazunari Ishii
• Keywords: Electrocardiography; Sarcoidosis; Fluorodeoxyglucose F18; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Cytomegalovirus Infections; Humans

The aim of this study was to estimate the impact of respiratory and electrocardiogram (ECG)-gated FDG positron emission tomography (PET)/computed tomography (CT) on the diagnosis of cardiac sarcoidosis (CS).Imaging from thirty-one patients was acquired on a PET/CT scanner equipped with a respiratory- and ECG-gating system. Non-gated PET images and three kinds of gated PET/CT images were created from identical list-mode clinical PET data: respiratory-gated PET during expiration (EX), ECG-gated PET at end diastole (ED), and ECG-gated PET at end systole (ES). The maximum standardized uptake value (SUVmax) and cardiac metabolic volume (CMV) were measured, and the locations of FDG accumulation were analyzed using a polar map. The mean SUVmax of the subjects was significantly higher after application of either respiratory-gated or ECG-gated reconstruction. Conversely, the mean CMV was significantly lower following the application of respiratory-gated or ECG-gated reconstruction. The segment showing maximum accumulation was shifted to the adjacent segment in 25.8%, 38.7%, and 41.9% of cases in EX, ED, and ES images, respectively.In FDG PET/CT scanning for the diagnosis of CS, gated scanning is likely to increase quantitative accuracy, but the effect depends on the location and synchronization method.