BDNF levels are increased in peripheral blood of middle-aged amateur runners with no changes on histone H4 acetylation levels

• DOI: 10.1007/s12576-016-0496-6
• Publication Date: 2016-10-14T15:49:47Z
• Authors: Fernanda Peres da...; Carla Basso; Wagner Raupp; Morgana Dalpiaz; Karine Bertoldi; Ionara Rodrigues ...; Pedro Dal Lago; Maristela Padilha...; Viviane Rostirola...
• Keywords: Adult; Male; 0301 basic medicine; Brain-Derived Neurotrophic Factor; Acetylation; Middle Aged; Running; Histones; 03 medical and health sciences; Case-Control Studies; Leukocytes, Mononuclear; Humans; Sedentary Behavior

Our aim was to compare the basal levels of plasma brain-derived neurotrophic factor (BDNF) and global histone H4 acetylation in peripheral blood mononuclear cells (PBMCs) healthy amateur runners (EXE group) with sedentary individuals (SED as well investigate acute effect a running race on these markers EXE group. Five days before race, all participants were submitted collection. On day, two samples collected group started immediately at end. In period, significant increase BDNF when compared SED (p = 0.036) demonstrated, while no difference observed. These parameters unaltered after race. The increased might be linked middle-aged runners’ phenotype.