The Role of Baseline Sarcopenia Index in Predicting Chemotherapy-Induced Undesirable Effects and Mortality in Older People with Stage III or IV Non-Small Cell Lung Cancer

• DOI: 10.1007/s12603-021-1633-3
• Publication Date: 2021-04-26T11:43:06Z
• Authors: Xiaoyan Chen; Lisha Hou; Y. Shen; X. Wu; B. Dong; Qiukui Hao
• Keywords: Bone marrow suppression

To assess the predictability value of Sarcopenia index((SI, serum creatinine value/cystatin C value×100) in determining potential chemotherapy-induced undesirable reactions and eventual death older patients diagnosed with stage III or IV non-small cell lung cancer (NSCLC). General information was retrieved from health records mortality data obtained by phone interview. Serum Cr CysC levels were measured before chemotherapy. The endpoints recorded any causes. Logit regression analysis employed for correlation between SI short-term adverse to Cox analyze mortality. In this study, 664 NSCLC enrolled. Among them, 83.13% adenocarcinoma 16.87% squamous carcinoma cancer. As March 1, 2019, 486 died, including 361(74.28%) males 125 (25.72%) females. After first course chemotherapy, proportion reactions, bone marrow suppression, digestive all infection, liver function impairment, other (non-infectious fever rashes) 16%, 4.7%, 7.4, %, 6.6%, 2.11%, respectively. adjusting confounding factors, there no association reactions. We found that high independently associated a lower risk after factors females (HR=0.593,95% CI: 0.382–0.92; p=0.02). There marked existed males. cancer, is females, but not