Perforation following pneumatic dilation of achalasia cardia in a university hospital in northern India: A two-decade experience

• DOI: 10.1007/s12664-018-0874-5
• Publication Date: 2018-08-18T04:59:48Z
• Authors: Uday C. Ghoshal; Arun Karyampudi; Abhai Verma; Hemanta K. Nayak; Samir Mohindra; Nakul Morakhia; Vivek A. Saraswat
• Keywords: Adult; Aged, 80 and over; Male; Esophageal Perforation; Time Factors; Adolescent; India; Middle Aged; Dilatation; 3. Good health; Esophageal Achalasia; Hospitals, University; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Aged; Retrospective Studies

Pneumatic dilation (PD) is a cost-effective first-line treatment for achalasia. The most feared complication of PD is esophageal perforation (EP). As data on EP after PD for achalasia are not widely reported, we present the frequency, risk factors, and treatment-outcome of EP. Records of patients undergoing PD for achalasia (January 1995 to September 2015) were retrospectively reviewed. Of 433 patients (age 38 years, 13-88, 57% male), and 521 dilations, 12 were complicated by EP (2.7% of patients and 2.3% of PD). EP occurred in 7 (3.4%), 4 (1.7%), and 1 (4.1%) with use of balloon diameters 30, 35, and 40 mm, respectively. In most (11/12, 92%), EP occurred during the first PD. No risk factor for EP was identified (p = 0.65 for the first dilation vs. > 1 dilation, and 0.75 for balloon size of 30 mm vs. > 30 mm). Seven patients with contrast leak on esophagogram and/or computed tomography scan underwent surgery. One other with contrast leak was successfully treated with a fully covered self-expandable metal stent (FC-SEMS); the remaining four with small leak/pneumomediastinum were managed conservatively. The median duration of hospital stay following perforation was 13 days (7-26) and 8 days (6-10) in surgery and conservative groups, respectively. No mortality was observed in either group. The frequency of EP with PD was 2.3%. Though most EP (92%) occurred during the first dilation, neither the balloon size nor repeated dilations were identified as risk factors. Both surgical and conservative approaches had a favorable outcome in appropriate settings.