Propofol inhibits colon cancer cell stemness and epithelial-mesenchymal transition by regulating SIRT1, Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways

• DOI: 10.1007/s12672-023-00734-y
• Publication Date: 2023-07-25T13:02:27Z
• Authors: Runjia Wang; Shuai Li; Qi Hou; Bo Zhang; Huaqing Chu; Yu Hou; Cheng Ni; Li Sun; Yuliang Ran; Hui Zheng
• Keywords: Beta-catenin

Propofol is a common sedative-hypnotic drug used for general anesthesia. Recent studies have drawn attention to the antitumor effects of propofol, but potential mechanism by which propofol suppresses colon cancer stemness and epithelial-mesenchymal transition (EMT) has not been fully elucidated.