An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective

• DOI: 10.1007/s12672-024-01135-5
• Publication Date: 2024-07-12T08:02:19Z
• Authors: Yi Yin; Yong Li; Yaoyang Zhang; Qiucheng Jia; Huiming Tang; Jiming Chen; Rui Ji
• Keywords: GAB2; Immune infiltration; 0301 basic medicine; 03 medical and health sciences; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Phosphorylation; Prognosis; RC254-282; Analysis; Cancer

Abstract Background To explore the role of GAB2 in pan-cancer based on bioinformatics analysis. Methods Based TCGA and GTEx databases, we used TIMER2.0 online analysis tool R language to analyze expression pan-cancer. We Kaplan–Meier Plotter relationship between OS RFS utilized CPTAC database examine phosphorylated investigated effects mutation features occurrence development human cancers by cBioPortal COSMIC. Using database, conducted an molecular compounds that have potential interact with through docking. Moreover, use TIMER immune cell infiltration, draw relevant heatmaps language. Results was abnormally expressed various tumors associated prognosis. There were differences phosphorylation tumor tissues corresponding normal among different types tumors. interacts Docetaxel infiltration Conclusion participates regulating affects prognosis patients. may serve as a marker.