MUC5B regulates alterations in the immune microenvironment in nasopharyngeal carcinoma via the Wnt/β-catenin signaling pathway

• DOI: 10.1007/s12672-025-01772-4
• Publication Date: 2025-01-09T13:13:25Z
• Authors: Hongming Wang
• Keywords: Wnt signaling pathway; Oligomeric mucus/gel-forming; Research; Nasopharyngeal carcinoma; Mucin 5B; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Immunization; β-catenin; RC254-282

To screen potential differentially expressed genes related to immune function in nasopharyngeal carcinoma through an online database, and verify their mechanism of action, so as provide a reference for the diagnosis treatment future. Differentially were analyzed from GSE227541 dataset, functional enrichment analysis was conducted. With mucin 5B, oligomeric mucus/gel-forming focus, correlation between its expression indexes by using TIMER database. The expressions clinical NPC tissues adjacent tissue samples detected Furthermore, abnormal vectors constructed transfected into human cell CNE-2Z detect alterations activity, ferroptosis microenvironment. In addition, role Wnt/β-catenin signaling pathway observed, influence on this discussed. A total 42 found among which obviously at core entire network. tissues, research team observed upregulated (P < 0.05). vitro, increased elevated activates activity escape inhibits ferroptosis. terms pathways, upregulating could activate pathway. Mucin regulates cells participates tumor progression mediating