Deciphering the risk of developing liver cancer following gastric cancer diagnosis with genetic evidence: a Mendelian randomization analysis in an East Asian population

• DOI: 10.1007/s12672-025-01938-0
• Publication Date: 2025-02-12T11:25:52Z
• Authors: Jiansheng Chen; Aiming Zeng; Yunzhe Yu; Liqun Liao; Siwei Huang; Sida Sun; Weijie Wu
• Keywords: Mendelian Randomization; Mendelian inheritance; Liver Cancer

Liver cancer is a common second primary in gastric patients, but whether diagnosis contributes to the development of liver remains contentious. This study aims utilize Mendelian randomization (MR) analysis investigate potential causal relationship between and from genetic perspective. We extracted single nucleotide polymorphism for East Asian population Genome-Wide Association Studies database as instrumental variables employed univariate multivariate MR evaluate cancer. The robustness findings was ensured through heterogeneity sensitivity analyses. Univariate revealed that susceptibility significantly associated with an increased risk [Inverse-variance weighted (IVW): OR = 1.252, 95% CI 1.076–1.457, P 0.004]. Multivariate indicated after adjusting confounding factors, significant positive remained robust (all < 0.05). Furthermore, no observed (IVW: 1.111, 0.936–1.318, 0.228). Genetic prediction results suggest survivors might face developing cancer, implying value routine screening survivors.