Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice

• DOI: 10.1007/s12975-019-00763-2
• Publication Date: 2019-12-21T14:02:20Z
• Authors: Michael J. Haley; Claire S. White; Daisy Roberts; Kelly O’Toole; Catriona J. Cunni...; Jack Rivers-Auty; Conor O’Boyle; Conor Lane; Oliver Heaney; Stuart M. Allan; Catherine B. Lawr...
• Keywords: Stroke; Neurochemistry; Vascular surgery

Abstract During recovery, stroke patients are at risk of developing long-term complications that impact quality life, including changes in body weight and composition, depression anxiety, as well an increased subsequent vascular events. The aetiologies time-course these post-stroke have not been extensively studied poorly understood. Therefore, we assessed metabolic markers behaviour after middle cerebral artery occlusion mice. These outcomes were also the context obesity, a common co-morbidity proposed to protect against loss patients. We found induced characterised by sustained fat mass with recovery lean loss. global response accompanied altered lipid profile (increased plasma free fatty acids triglycerides) adipokine release 60 days. After stroke, liver showed histological indicative damage decrease alanine aminotransferase (ALT) was observed. Stroke anxiety-like behaviours mice, illustrated deficits exploration, nest building burrowing behaviours. When initial infarct volumes matched between mice without comorbid drastically altered. Overall, depressive/anxiety-like behaviours, lipids, adipokines may negatively on future health.