Reparative System Arising from CCR2(+) Monocyte Conversion Attenuates Neuroinflammation Following Ischemic Stroke

• DOI: 10.1007/s12975-020-00878-x
• Publication Date: 2021-01-06T19:09:29Z
• Authors: Joohyun Park; Jong Youl Kim; Yu Rim Kim; Meiying Huang; Ji Young Chang; A Young Sim; Hosung Jung; Won Taek Lee; Young-Min Hyun; Jong Eun Lee
• Keywords: CCR2; CX3CR1; Monocyte; Stroke

Abstract Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical that express CCR2 high CX3CR1 low circulate in blood, anti-inflammatory non-classical patrol locally. In this study of transgenic mice with functional GFP/+ -CCR2 RFP/+ , we found recruited injured brain were cytokine-dependently converted macrophages, especially under influence IL-4 IL-13, thereby attenuating neuroinflammation sterile stroke. The overall data suggest (1) regulation monocyte-switching one ultimate reparative strategies stroke, (2) adaptation a locally milieu vital alleviating effects through innate immunity.