Early decrease in blood platelet count is associated with poor prognosis in COVID-19 patients—indications for predictive, preventive, and personalized medical approach

• DOI: 10.1007/s13167-020-00208-z
• Publication Date: 2020-05-14T18:13:45Z
• Authors: Xiaofang Zhao; Kun Wang; Peiyuan Zuo; Yuwei Liu; Meng Zhang; Songpu Xie; Hao Zhang; Xinglin Chen; Chengyun Liu
• Keywords: Clinical Significance; Absolute neutrophil count

Changes in platelet count are common COVID-19 patients. The reflects the thrombocyte turnover, acting as a sensitive indicator of illness severity that is great clinical utility to monitor quickly changing health condition patients affected by aggressive viral infections. This study aims investigate significance during progression disease patients.A total 532 were involved cohort from First People's Hospital Jiangxia District Wuhan January 7, 2020, February 28, 2020. We collected characteristics and laboratory data Patients still hospitalized before 29, died on admission, with malignant tumors, previous gastrointestinal surgery, missing baseline count, or detected only once, excluded. used generalized additive model mixed compare trends over time among survivors non-survivors, an adjustment for potential confounders.During follow-up, twenty-nine subjects (mortality rate, 5.45%). platelets non-survivors decreased increased gradually within 1 week after admission. In addition, difference between two groups showed increasing trend average 5.3 × 10^9/L daily.In early stage, can dynamically reflect pathophysiological changes Early decrease was associated mortality COVID-19. Causality, however, cannot be deduced our data.