Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine

• DOI: 10.1007/s13167-022-00298-x
• Publication Date: 2022-09-26T06:02:32Z
• Authors: Zhiyuan Wu; Haiping Zhang; Zhiwei Li; Haibin Li; Xinlei Miao; Huiying Pan; Jinqi Wang; Xiangtong Liu; Xiaoping Kang; Xia Li; Lixin Tao; Xiuhua Guo
• Keywords: 0301 basic medicine; Brachial-ankle pulse wave velocity; Biomedical and clinical sciences; Research; 610; Health sciences; Diseases; FOS: Health sciences; Cardiovascular risk; Arterial stiffness; Predictive preventive and personalized medicine (PPPM / 3PM); 3. Good health; Mutual effect; 03 medical and health sciences; 0302 clinical medicine; Medicine and Health Sciences; Health services and systems; Homocysteine; Uric acid

Arterial stiffness is a major risk factor and effective predictor of cardiovascular diseases common pathway pathological vascular impairments. Homocysteine (Hcy) uric acid (UA) own the shared metabolic pathways to affect function. Serum has great impact on arterial risk, while mutual effect with Hcy remains unknown yet. This study aimed evaluate serum UA 10-year in general population. From perspective predictive, preventive, personalized medicine (PPPM/3PM), we assumed that combined assessment provides better tool for targeted prevention intervention via suppressing stiffness.This consisted 17,697 participants from Beijing Health Management Cohort, who underwent health examination between January 2012 December 2019. Brachial-ankle pulse wave velocity (baPWV) was used as an index stiffness.Individuals both high had highest baPWV, compared those low (β: 30.76, 95% CI: 18.36-43.16 males; β: 53.53, 38.46-68.60 females). In addition, these individuals owned (OR: 1.49, 1.26-1.76 OR: 7.61, 4.63-12.68 Of note, males homocysteine were significantly associated increased 1.30, 1.15-1.47), but not group 1.02, 0.90-1.16).This found using large population suggested clinical importance evaluation control promoting health. The adverse arteriosclerosis should be addressed beyond acid, especially males. Monitoring level window opportunity PPPM/3PM progression CVD. novel identify at primary early treatment progressive stage stiffness, active levels aspects dietary behavior medication conducive alleviating reducing Further studies are needed health.The online version contains supplementary material available 10.1007/s13167-022-00298-x.