Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression

• DOI: 10.1007/s13238-015-0156-2
• Publication Date: 2015-05-11T05:47:39Z
• Authors: Jing Li; Yujing Zhang; Dameng Li; Yuchen Liu; Danping Chu; Xiaohong Jiang; Dongxia Hou; Ke Zen; Chen-Yu Zhang
• Keywords: Transplacental

Increasing evidence demonstrated that exogenous plant miRNAs in the diet can be absorbed and are found mammalian tissues.These influence physiological pathological progression of recipient.In this issue, Jing Li colleagues further reveal exogenous/ endogenous small non-coding RNA maternal system transfer through placenta to fetal side development health.These surprising finding demonstrate profiling very important development, which means healthy status may postnatal morbidity via transplacental RNAs.Furthermore, also proposes a brand new potential strategy treat diseases utero.Combining with gene therapy, administrating represents trend for treating diseases.-Yali Hiu