Skeletal involvement in Langerhans cell histiocytosis

• DOI: 10.1007/s13244-013-0271-7
• Publication Date: 2013-08-01T06:20:57Z
• Authors: Suonita Khung; Jean-François Budzik; Elisa Amzallag-Be...; Anne Lambilliote; Gustavo Soto Ares; Anne Cotten; Nathalie Boutry
• Keywords: Langerhans Cell Histiocytosis; Cranial vault; Neuroradiology; Vertebra; Eosinophilic granuloma; Osteolysis

Langerhans cell histiocytosis (LCH) represents a disorder characterised by an abnormal accumulation of histiocytes in miscellaneous tissues. The bone is commonly affected, especially the flat bones, spine and long bones. Some lesions children such as "vertebra plana" or solitary lytic lesion skull may be suggestive for LCH, whereas others can confused with malignant tumour osteomyelitis. This pictorial essay presents main usual unusual skeletal manifestations observed LCH.• Osseous involvement LCH very similar to that seen multiple myeloma. • A cranial vault typical radiographic finding LCH. vertebra plana appearance another finding. Extensive signal intensity changes within marrow on MRI are helpful sign diagnosis. In endosteal scalloping responsible "budding appearance".