IRF-2 is over-expressed in pancreatic cancer and promotes the growth of pancreatic cancer cells

• DOI: 10.1007/s13277-011-0273-3
• Publication Date: 2011-11-25T04:08:16Z
• Authors: Lei Cui; Yuezhen Deng; Yefei Rong; Wenhui Lou; Zhengfa Mao; Yuanyuan Feng; Dong Xie; Dayong Jin
• Keywords: Adult; Male; 0301 basic medicine; Middle Aged; Up-Regulation; 3. Good health; Pancreatic Neoplasms; 03 medical and health sciences; Cell Transformation, Neoplastic; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Female; Pancreas; Interferon Regulatory Factor-2; Cell Proliferation

Pancreatic cancer is one of the most malignant diseases in world. Interferon regulator factor 2 (IRF-2), an interferon regulatory factor, has been known to act as oncogene distinct types cancer. In this study, we found that expression IRF-2 was up-regulated primary pancreatic samples and associated with tumor size, differentiation, tumor–node–metastasis stage, survival patients. cells, knockdown on inhibited cell growth liquid culture soft agar. Mechanistically, modulated cells through regulating proliferation apoptosis effectors, such cyclin D1 BAX. Collectively, these results suggest plays important role tumorigenesis down-regulation would be a new treatment target for